Anthroposophic medicine is an integrative multimodal treatment system based on a holistic understanding of man and nature and of disease and treatment. It builds on a concept of four levels of formative forces and on the model of a three-fold human constitution. Anthroposophic medicine is integrated with conventional medicine in large hospitals and medical practices. It applies medicines derived from plants, minerals, and animals; art therapy, eurythmy therapy, and rhythmical massage; counseling; psychotherapy; and specific nursing techniques such as external embrocation. Anthroposophic healthcare is provided by medical doctors, therapists, and nurses. A Health-Technology Assessment Report and its recent update identified 265 clinical studies on the efficacy and effectiveness of anthroposophic medicine. The outcomes were described as predominantly positive. These studies as well as a variety of specific safety studies found no major risk but good tolerability. Economic analyses found a favorable cost structure. Patients report high satisfaction with anthroposophic healthcare.
人智医学是一种综合性的多模式治疗体系，它建立在对人类与大自然，以及对病症和治疗的整体理解之上。其基础为四层构成力概念和三重人体体质模型。在大型医院以及实际的医疗实践中，人智医学与传统医学是结合在一起使用的。它采用从植物、矿物和动物中提取的药物；采用艺术疗法、精神疗法和节律性按摩；采用咨询、心理治疗和特种护理技术，比如外用搽剂等。人智医疗由医生、治疗师和护士提供。一项卫生技术评估报告及其最近的更新文档列举了 265 项针对人智医学效用和效益的临床研究。其研究结果被阐述为这种疗法具有压倒性的正面优势。这些研究以及其他各种特定的安全性研究并没有发现其重大的风险，而是提示具有很好的耐受性。经济分析也发现它具有有利的成本构
La medicina antroposófica es un sistema de tratamiento multimodal integrador que se basa en un entendimiento holístico del hombre y la naturaleza, así como de la enfermedad y del tratamiento. Se desarrolla sobre un concepto de cuatro niveles de fuerzas formativas y sobre el modelo de una constitución humana en tres partes. La medicina antroposófica se integra con la medicina convencional en grandes hospitales y en consultorios médicos. Aplica medicamentos de origen vegetal, mineral y animal; terapias artísticas, euritmia curativa y masaje rítmico; orientación, psicoterapia y técnicas de enfermería específicas, tales como la frotación externa. La atención sanitaria antroposófica es realizada por médicos, terapeutas y personal de enfermería. En un informe de evaluación de la tecnología sanitaria y en su reciente actualización se identificaron 265 estudios clínicos sobre la eficacia y la efectividad de la medicina antroposófica. Los resultados se describieron como predominantemente positivos. Estos estudios, así como diversos estudios de seguridad específicos, no encontraron ningún riesgo importante y sí una buena tolerabilidad. Los análisis económicos revelaron una estructura de costes favorable. Los pacientes indican una alta satisfacción con la atención sanitaria antroposófica.
ANTHROPOSOPHY AS A SPIRITUAL SCIENCE
Anthroposophic medicine is based on the cognitive methods and cognitive results of anthroposophy.1 Anthroposophy was established by Rudolf Steiner (1861-1925).2 After studying empirical sciences, mathematics, and philosophy in Vienna, Steiner was commissioned at the age of 22 to publish Johann Wolfgang Goethe’s scientific writings in Kürschners Deutscher Nationalliteratur (German National Literature) and collaborated on the Sophie Edition of Goethe’s works in Weimar.3,4 Steiner began developing anthroposophy in 1901.5 Anthroposophy is a view on humanity and nature that is spiritual and that at the same time regards itself to be profoundly scientific.6 Steiner considered anthroposophy a consequential evolutionary step in the development of Western thought.7 In anthroposophy, three traditions are integrated and enhanced: the empirical tradition of modern science as started by Copernicus, Kepler, and Galileo; the cognitional tradition of philosophy as initiated by Plato and Aristotle and as brought to a culmination in so-called German idealism by Hegel, Fichte, Schelling, Schiller and Goethe; and finally the esoteric tradition of Christian spirituality. The stability of this integration was reflected in Steiner’s critique and rejection of the philosophy of Kant8 and of materialistic reductionism.3 Kant had propagated the idea that there were definite limitations to scientific knowledge,9 and the materialistic reductionism movement had declared the interactions of material particles to be the basic principle of all scientific explanation.10–12 In contrast, Steiner proposed and described how human beings could expand their cognitive capacities and how these expanded capacities6 could be implied to investigate a variety of formative forces that are, beyond particle interactions, effective in organisms (Sidebar 1).13
The Four-level Concept of Formative Forces13
The anthroposophic concept of the human being claims that the human organism is not only formed by physical (cellular, molecular) forces but by a total of four levels of formative forces: (1) formative physical forces; (2) formative growth forces that interact with physical forces and bring about and maintain the living form, as in plants; (3) a further class of formative forces (anima, soul) that interact with the growth forces and physical forces, creating the duality of internal-external and the sensory, motor, nervous and circulatory systems as seen in animals; (4) an additional class of formative forces (Geist, spirit) that interacts with the three others and supports the expression of the individual mind and the capacity for reflective thinking, which is unique for humans.
When the four levels of formative forces are integrated with the human polarity of active motor movement and passive sensory perception, the three-fold constitution of the human being comes into being. It embraces three major systems: two being polar to each other (nerve-sense system and motor-metabolic system), and one being intermediate (rhythmic system). These subsystems are spread over the entire organism but predominate in certain regions: the nerve-sense system in the head region, the motor-metabolic system in the limb region, the rhythmic system in the respiratory and circulatory organs and thus in the “middle” region.
In these three subsystems, the four levels of formative forces are considered to interrelate differently. In the nerve-sense system, the upper two levels of forces (spirit, soul) are relatively separate from the lower two levels, thus providing the conditions for the origination of self-consciousness, conscious perceptions, and conscious thought processes. In the motor-metabolic system, the interpenetration is closer, thus providing the conditions for the execution of personally intended bodily movements. In the rhythmic system, the interrelations of the upper and lower levels fluctuate between increasing and decreasing connection and are associated with the origination of emotion; the interpenetration increases during the rhythmical lung process of inspiration and decreases during expiration.
The model of the three-fold human constitution leads to distinct re-interpretations of the conventional teachings of physiology.
The concept of a multilevel organism with diverse subsystems is compatible with modern system approaches in developmental biology and with holistic models of cancer.16–18 In anthroposophy, the concept of the formative forces is rather elaborate and is also accompanied by a corresponding concept of material matter. The physical structures of matter are considered only one level, and when a substance is absorbed into the context of an organism, the substance becomes “enlivened” or even “ensouled.”1 The investigation of the formative forces and their material correspondences and of the diverse interrelations among these forces provides the basis for the anthroposophic worldview. This view brings spiritual dimensions to the natural sciences.6
Steiner provided anthroposophy with a deeply reflected epistemology.3–5,7,8,19–21 On the other hand, anthroposophy has proven to be not only a philosophy or a new orientation in science but also to be practically applicable. It induced a large variety of developments in different fields: a School of Spiritual Science with various specialized sections, founded in 1924 in Dornach, Switzerland; a new method of education (Waldorf schools, also known as Rudolf Steiner schools), currently with more than 1000 schools and approximately 2000 kindergartens, home programs, child care centers, and preschools worldwide; the curative education movement, which currently has more than 600 centers for curative education and social therapy worldwide for children, young people, and adults with disabilities and developmental problems; a new direction in agriculture, biodynamic farming; the creation of an art of movement, eurythmy; a renewal of various artistic practices such as recitation, dramatic art, painting, sculpture, and architecture; and attempts to reshape social life (three-fold social order22,23). One anthroposophic enterprise, Sekem, in Egypt,24 has been honored with the alternative Nobel Prize and with the Schwab Foundation Prize. Anthroposophic insights have been integrated into modern culture; numerous people in public life, commerce, banking, politics, culture, theatre and film, literature, the fine arts, music, fashion, and medicine have emerged from the anthroposophic scene.
BASIC PERSPECTIVES OF ANTHROPOSOPHIC MEDICINE
The etiologies and pathogeneses of diseases are concretely understood as abnormal interactions among the different levels of the human organism and its three subsystems (Sidebar 1).25,26 Reflecting upon these interactions is the basis for specific anthroposophic medical and treatment schedules. An example of such a diagnostic and therapeutic procedure has recently been outlined in a case report on anxiety and eurythmy therapy.27
Another basic aspect comes from the following: Once the existence and effectiveness of formative forces are taken into account, another view on the evolution of humanity and nature emerges, with specific relationships between the generating processes of the forms and substances in external nature and in the human body. Pathological deviations in the human organism can thus be seen in correspondence with formative processes and substances in nature. These correspondences are like those between keys and keyholes. Such or similar relations have been recognized in all cultures, even in humanity’s earliest times. Assessing these relationships can enable rational medicinal therapies.1
Guiding principles of anthroposophic healthcare are recognizing the autonomy and dignity of the patient and helping people to help themselves. Self-responsibility is addressed, and therapeutic goals are to stimulate different forms of self-healing—to stimulate hygiogenesis,28 which means to create a coherent autonomic regulation of the organism; and salutogenesis,29 which means to create a coherent psycho-emotional and spiritual self-regulation.30 The treatments do not merely intend to restore a former healthy condition, a “restitution ad integrum,” but to provoke a new level of the organism’s and the individual’s inner strength.13
Anthroposophic medicine thus pursues a holistic approach. Rather than focusing on a singular pathological datum, the aim is to strengthen the whole constitution of the sick patient, taking into account all dimensions: physical, emotional, mental, spiritual, and social. Treatments therefore often are multimodal. They are individually tailored in an attempt to synergize the effects of the different therapeutic components and so to enhance the chances for health improvement. Such treatment is conceived as a therapeutic system.31–33
PRACTICE AND FACILITIES OF ANTHROPOSOPHIC MEDICINE
Anthroposophic medicine is practiced in both inpatient and outpatient settings by trained medical doctors. Currently there are approximately 24 anthroposophic medical institutions, which include hospitals, departments in hospitals, rehabilitation centers, and other inpatient healthcare centers in Germany, Switzerland, Sweden, Italy, The Netherlands, and the United States (Sidebars 2 and 3 and Figure 1). In Germany, three large anthroposophic hospitals provide accident and emergency services within the requirement plans of the German Federal States (Bundesländer); two of them are academic teaching hospitals linked to neighboring universities (Sidebar 3). They provide specialty training for physicians. In 1983, the first private, nonstate university in Germany was founded out of one of these hospitals (University of Witten/Herdecke). In addition to the anthroposophic hospitals, there are more than 180 anthroposophic outpatient clinics worldwide in which anthroposophic physicians and therapists work together. Anthroposophic physicians also work in their own practices. Additionally, a variety of outpatient departments at large hospitals provide anthroposophic healthcare and consultation service (eg, Center for Integrative Medicine, Cantonal Hospital St Gallen, Switzerland; Institute of Complementary Medicine, University of Berne, Switzerland; Center for Complementary Medicine, University of Freiburg, Germany). Practitioners of anthroposophic medicine were decisively involved in the implementation of the liberal and pluralistic healthcare in Germany and in the relevant formulation of the German Medicines Act in 1976. Since 1976, anthroposophic medicine in Germany has been defined, alongside homeopathy and phytotherapy, as a distinct “special therapy system” (besondere Therapierichtung) in the Medicines Act34 and is represented in Germany by its own committee at the Federal Institute for Drugs and Medical Devices. Also, Switzerland and Latvia have recognized anthroposophic medicine as a distinct therapy system. In some countries, legal recognition is restricted to pharmaceutical regulation. The authorization, registration, and supervision of the profession of anthroposophic doctors are delegated to national medical associations.
Gemeinschaftskrankenhaus Havelhöhe, D-Berlin (Sidebar 3)
Gemeinschaftskrankenhaus Herdecke, D-Herdecke (Sidebar 3)
Filderklinic, D-Filderstadt: Internal medicine, oncology, cardiology, gastroenterology, emergency and intensive care medicine, gynecology and obstetrics, pediatric medicine, pediatric psychiatry, neonatology, surgery, anesthesia, radiology, psychosomatic medicine
Ita Wegman Klinik, CH-Arlesheim: Internal medicine (with oncology, cardiology, neurology, respiratory medicine, geriatrics), psychiatry, psychosomatic medicine
Paracelsus-Spital, CH-Richterswil: Surgery, urology, internal medicine, oncology, gastroenterology, respiratory medicine, cardiology, gynecology and obstetrics, radiology, anesthesia, emergency department, palliative care
Vidarkliniken, S-Järna: Rehabilitation (cancer, stress-related diseases, chronic pain), palliative care (cancer)
Specialty Hospitals and Departments
Asklepios – West Hospital Hamburg, Center for Holistic Medicine, D-Hamburg: Internal medicine, psychosomatic medicine
Lahnhöhe Hospital, D-Lahnstein: Psychosomatic medicine
Öschelbronn Hospital, D-Öschelbronn: Internal medicine, oncology
Paracelsus Hospital, D-Bad Liebenzell-Unterlengenhardt: Internal medicine
Klinikum (Hospital) Heidenheim, D-Heidenheim: General medicine
Friedrich-Husemann-Klinik, D-Buchenbach: Psychiatry
Lukas Clinic, CH-Arlesheim: Integrative tumor therapy and supportive care
Hospital Emmental – Department of Complementary Medicine, CH-Langnau i.E.: General, oncology, palliative, and psychosomatic medicine.
Hospital Scuol – Department of Complementary Medicine, CH-Scuol: General, oncology, palliative and psychosomatic medicine, perioperative care
Lievegoed Klinik, NL-Bilthoven: Psychiatry
Rehabilitation and Other Inpatient Healthcare Centers
Alexander von Humboldt Klinik, D-Bad Steben: Geriatric rehabilitation center
Sanatorium Sonneneck, D-Badenweiler
Reha-Klinik Schloss Hamborn, D-Borchen über Paderborn
Haus am Stalten, D-Steinen
Höfe am Belchen, D-Kleines Wiesental – Neuenweg: Therapeutic Community for Children and Young Persons’ Psychiatry
Heilstätte Sieben Zwerge, D-Salem-Oberstenweiler: Drug-related diseases,
Mutter und Kind Kurheim Alpenhof, D-Rettenberg
Casa di Cura Andrea Cristoforo, CH-Ascona
Casa die Salute Rapael, I-Roncegno (Trento)
Rudolf Steiner Health Center, Ann Arbor, Michigan, United States: Therapy and training center for chronic illnesses
Abbreviations: CH, Switzerland (Confoederatio Helvetica); D, Germany (Deutschland); I: Italy; NL, Netherlands; S, Sweden.
Gemeinschaftskrankenhaus Herdecke, a tertiary care center and academic teaching hospital founded in 1969, is responsible for providing acute inpatient services for the town of Herdecke and its immediate and more distant surrounding areas, including emergency medical services (level II and level III care). Anthroposophic medical care—medication, nursing care, physiotherapy, therapeutic baths, rhythmical massage, therapeutic riding, ergotherapy, speech therapy, psychotherapy, eurythmy therapy, art therapies (using music, painting, sculpture, speech therapy)—is integrated into the following specialty departments:
Anesthesia, including pain therapy.
Surgery: general, abdominal, trauma surgery including endoprosthesis, plastic, vascular and thoracic, oncological surgery, minor pediatric surgical procedures.
Gynecology and obstetrics: approximately 900 births/year.
Interdisciplinary early rehabilitation.
Internal medicine: cardiology, gastroenterology, respiratory medicine, psychosomatic medicine.
Interdisciplinary oncology: ward, day clinic, outpatient department, patient counseling, psychooncology.
Pediatrics: pediatric diabetes and endocrinology, diabetes training, therapy center; neuropediatrics with a special focus on epilepsy with digital electroencephalogram (EEG), EEG monitoring, video EEG; developmental retardation services; pediatric oncology and hematology, collaboration with the Society for Pediatric Oncology and Hematology; neonatology, pediatric intensive care medicine; pediatric and adolescent psychiatry, day hospital and secure ward with compulsory care, psychotraumatology (eg, posttraumatic stress disorder), eye movement desensitization and reprocessing, attention deficit/hyperactivity disorder, family therapy, psychosomatic medicine.
Neurology, including a department for spinal cord injuries, stroke, paraplegia.
Emergency admission/intensive care medicine/intermediate care unit.
Adult psychiatry: acute and intensive care ward, secure ward with compulsory care, day hospital.
Radiology: x-ray, ultrasound, computer tomography, digital subtraction angiography, magnetic resonance imaging.
Various departments provide outpatient consultations and treatment.
Gemeinschaftskrankenhaus Havelhöhe, taken over in 1995 and reorganized as a hospital for anthroposophic medicine, is an acute hospital with 304 beds providing acute inpatient services for the surrounding area.
Anthroposophic medical care—including medication, nursing care, eurythmy therapy, art therapies (using music, painting, sculpting), rhythmical massage, massage using the Dr Pressel method, psychotherapy, physiotherapy, exercises, and manual lymph drainage—is integrated into the following specialty departments, with further interdisciplinary competence centers and interdisciplinary cooperation in the treatment of tumors:
Internal medicine: General, oncology, diabetes (with a diabetes education center, type I and II), gastroenterology (endoscopy: gastroscopy, colonoscopy, endoscopic retrograde cholangiopancreatography, ballon-enteroscopy, endosonography, all interventional therapeutic procedures—such as polypectomy, mucosectomy, sclerotherapy, banding, stenting, ultrasound-guided drainage, endoscopic ultrasound-guided fine-needle aspiration, pH determination in esophagus and stomach, manometry, multipolare radiofrequency—cardiology (invasive and noninvasive investigations including cardiac catheter laboratory, percutaneous transluminal coronary angioplasty, stent implantation, pacemakers, Havelhöhe Heart School).
Palliative ward and pain ward including port insertion, feeding catheters, stents, epidural catheters, pumps, neurolytic blocks.
Respiratory medicine, including whole body plethysmography, sleep apnea investigations, flexible video-bronchoscopy, thoracoscopy, endobronchial ultrasound, filling of pneumonectomy cavities, allergen provocation and challenge testing and hyposensitization, determining the indications for long-term and domestic oxygen therapy).
Surgery: general and oncological, visceral, hand, orthopedics, trauma, center for minimally invasive surgery including natural orifice transluminal endoscopic surgery, vascular surgery, colorectal cancer center, outpatient and inpatient operations.
Gynecology and obstetrics (approximately 1200 births/year).
Drug withdrawal therapy (multiple drug users, heroin, alcohol).
Psychotherapeutic medicine, psychosomatic medicine.
Anesthesia, including pain therapy.
Interdisciplinary intensive care ward, including hemodialysis.
Radiology, myelography, angiography, and computed tomography, nuclear medicine (single-photon emission computed tomography camera, myocardial scintigraphy, brain perfusion scintigraphy).
Various departments provide outpatient consultations. Fifty percent of the patients are from outside the region, which is regarded as a manifestation of high acceptance by patients. Havelhöhe Hospital is an academic teaching hospital of the Charité.
Anthroposophic medicine is practiced by physicians with specialized training in anthroposophic as well as conventional medicine, and anthroposophic therapies are also prescribed by many other physicians with varying levels of training. Anthroposophic physicians often work in primary care, but anthroposophic medicine is not limited to general practice. It also is practiced in more specialized realms (Figure 2; Sidebar 3).
The certification requirements to become an anthroposophic physician are defined and regulated on national levels, which share similar curriculum. In Germany, for instance, the curricula requires 3 years of postgraduate medical practice, 1 year’s study of anthroposophic medicine according to a predefined program, and 2 years of medical practice under the guidance of a mentor. In addition, specific training courses are available in certain specialties. A further International Postgraduate Medical Training (IPMT) in anthroposophical medicine consists of a series of yearly week-long training and enables registered medical doctors to acquire a certificate of anthroposophic doctor after 3 years. Full curriculum training is available in several countries including Argentina, Australia, Austria, Brazil, Chile, Cuba, Denmark, Estonia, Finland, France, Georgia, Germany, Hungary, India, Israel, Italy, Japan, Latvia, The Netherlands, New Zealand, Norway, Peru, The Philippines, Poland, Romania, Russia, Spain, Switzerland, Taiwan, Ukraine, United Kingdom, and the United States. Several professorships for anthroposophic medicine exist, and postgraduate training is offered at a variety of universities/medical schools.
Guidelines for good professional practice set standards for anthroposophic physicians regarding ethical principles, training, certification, continuous medical education, professional conduct, relationship with colleagues and therapists, and social commitments. Internationally, anthroposophic physicians are represented by the International Federation of Anthroposophical Medical Associations (IVAA), which functions as an umbrella organization with regard to political and legal affairs.
Anthroposophic medicine employs, in addition to conventional treatments, special medications and special therapeutic procedures, including eurythmy therapy, rhythmical massage, anthroposophic art therapy, and counseling. In addition, there are special anthroposophic nursing techniques. The therapies can be used as monotherapy or combined with other anthroposophic therapies.
Plant, mineral, and animal substances are used in anthroposophic medications. Anthroposophic medications are conceived, developed, and produced in accordance with the anthroposophic knowledge of the human being, nature, and substance and are sometimes potentized. The method of production is specified in the German homeopathic pharmacopoeia, in the Swiss Pharmacopoeia, and in the Anthroposophic Pharmaceutical Codex and follows good manufacturing practice. The medications are administered orally, rectally, vaginally, parenterally (intracutaneously, subcutaneously, or intravenously), or topically (applied to the skin, conjunctival sac, or nasal cavity). Several pharmaceutical companies produce anthroposophic medicines (eg, Weleda, Arlesheim, Switzerland; Wala Heilmittel, Eckwälden, Germany; Abnoba Heilmittel, Pforzheim, Germany). In anthroposophic medical practice, homeopathic and herbal medicine preparations are also used, in addition to conventional pharmaceuticals if appropriate. The nonprofit, independent European Scientific Cooperative on Anthroposophic Medicinal Products (ESCAMP) investigates issues of system evaluation of anthroposophic medicine for regulatory purposes.
External applications—such as embrocation, compresses (Figure 3), hydrotherapy, and medicinal baths—are used as elements of nursing care and therapy to stimulate, strengthen, or regulate hygiogenic processes. For this purpose, etheric or fatty oils, essences, tinctures, and ointments are used, as well as carbon dioxide in baths. Of particular importance is rhythmical massage (described below).
In nursing care, the intention is to become acquainted with the whole patient and perceive the patient in his or her physical, psychological, and spiritual being. A caring bond is developed, which aims at developing a personal, accompanying, and mediating relationship with the patient. In affiliation with two anthroposophic hospitals (Gemeinschaftskrankenhaus Herdecke and Filderklinik, Filderstadt; Sidebar 2) state-recognized training institutes provide 3-year courses in anthroposophically extended nursing. In addition, several institutions provide further training opportunities.
Anthroposophic art therapy was developed mainly by Margarethe Hauschka,35 who also founded the first training institution for this form of therapy in 1962.36 Anthroposophic art therapy employs the following techniques:
Sculptural forming: Stone, soapstone, wood, clay, beeswax, plasticine, and sand are all used as sculpting materials.
Therapeutic drawing and painting: The materials used include paints and brushes, chalk, crayons, and paper.
Music therapy: Instruments used include percussion instruments such as the glockenspiel, xylophone, cymbals, resonant wooden blocks, drums and kettledrums; various wind instruments such as flute, crumhorn, shawm, trumpet, and alpenhorn; string instruments such as the chrotta (a simplified cello), violin, viola, and double-bass; and plucked instruments such as the harp, lyre and kantele. Melodies, sounds, and rhythms are improvised with the therapist or simply listened to. The choice of instrument depends on the individual circumstances of the patient, according to the severity and stage of the illness.
Anthroposophic speech therapy: This involves using articulation, consonants, vowels, text rhythms, and hexameters. Breathing plays a particular role in speaking (speech is formed exhalation). The indications for anthroposophic speech therapy are not only disorders of the voice but also general medical diseases, psychosomatic and psychiatric diseases, and learning and developmental difficulties.
Art therapy is provided as individual therapy, as individual therapy in small groups, or as group therapy. The patients learn to work specifically with the particular medium (such as painting or sculpture). Before the first treatment, there is a special session for obtaining an art-therapeutic anamnesis and diagnosis. Each succeeding therapy session usually lasts for 50 minutes and takes place once a week. Qualification as an anthroposophic art therapist requires 4 years’ college training and a 2-year period of professional experience under a mentor. In Germany and The Netherlands, master of arts degrees are possible.
Eurythmy therapy (In Greek, eurythmy means “harmonious rhythm”; Figure 4) is an exercise therapy involving cognitive, emotional, and volitional elements. It is provided by eurythmy therapists in individual or small group sessions during which patients are instructed to perform specific movements with the hands, the feet, or the whole body. Eurythmy therapy movements are related to the sounds of the vowels and consonants, to music intervals, or to soul gestures (eg sympathy-antipathy). For each patient, one movement is or several movements are selected depending on the patient’s disease, his constitution, and on the therapist’s observation of the patient’s movement pattern.27 This selection is based on a core set of principles, prescribing specific movements for specific diseases, constitutional types, and movement patterns.37,38 A therapy cycle usually consists of 12 to 15 sessions, each usually lasting 30 to 45 minutes; between sessions, patients practice the exercises daily. Qualification as an eurythmy therapist requires 5 and a half years of training according to an international standardized curriculum. Eurythmy therapy is believed to have both general effects (eg, improving breathing patterns and posture, strengthening muscle tone, enhancing physical vitality39) and disease-specific effects.38
Rhythmical massage was developed from Swedish massage by Wegman, who was a physician and physiotherapist. Traditional massage techniques are augmented by lifting movements, rhythmically undulating or gliding movements, and complex movement patterns such as lemniscates and by using special loosening techniques from the deeper areas out to the periphery. In addition to effects on the skin, subcutaneous tissues, and muscles, rhythmical massage is believed to have both general effects (eg, enhancing physical vitality) and disease-specific effects. Rhythmical massage is practiced by physiotherapists with additional 1.5 to 3 years of rhythmical massage training according to a standardized curriculum.
Anthroposophic Psychotherapy and Counseling
Psychotherapy has been extended by anthroposophic perspectives to anthroposophic psychotherapy. Full training is available in different countries, and a master’s/bachelor’s degree in anthroposophic psychotherapy is available in Germany, The Netherlands, Italy, and the United Kingdom. Counseling on biographical-existential, lifestyle, nutritional, social, mental, and spiritual issues is a central element of anthroposophic medical care.
RESEARCH ON ANTHROPOSOPHIC MEDICINE
Since its development in the 1920s and early 1930s, anthroposophic medicine has been associated with extensive research activities. After World War II, when anthroposophic medicine was re-established in Europe, the focus was on founding practices, clinics, and hospitals rather than on research. In the 1970s and 1980s, research was again performed but also restrained by the predominant paradigm of the double-blind randomized trial, which is difficult to implement for nonpharmacological treatments, counseling, and whole system treatment. Randomization and blinding often have been rejected by anthroposophic physicians and their patients due to strong therapy preferences and the focus on the physician-patient relationship and highly individualized treatment approaches.40,41 During the past 30 years, research activities have grown steadily, including laboratory work, preclinical studies, clinical trials and observational studies, epidemiological research, safety assessments, economic analyses, patient’s perspective assessments, systematic reviews, meta-analyses, and Health-Technology Assessment (HTA) reports. Intense work has been done on methodological issues, with a major focus on individualized therapy assessment, including systematic improvements of case report assessments.13 Research centers were set up at anthroposophic hospitals and universities. At present, research is particularly focused on the evaluation of the total system of anthroposophic medicine and, on the other hand, on individualized, personalized therapeutic approaches.
Clinical Efficacy and Effectiveness
The most comprehensive review of clinical efficacy and effectiveness of anthroposophic treatments—an HTA report and its update13,42—identified 265 studies. Thirty-eight of these studies were randomized controlled trials, 36 were prospective studies, and 49 were retrospective nonrandomized controlled studies. The remaining 142 studies were observational, without a comparison group.
The studies investigated a wide spectrum of anthroposophic treatments in a multitude of diseases: 38 evaluated the whole system of anthroposophic healthcare, 10 examined nonpharmacological therapies, 133 were devoted to anthroposophic mistletoe extracts in cancer, and 84 to other anthroposophic medication treatments. Methodological quality differed substantially; some studies showed major limitations and hardly allow valid conclusions regarding efficacy/effectiveness, while others were reasonably well-conducted.
Two-hundred fifty-three of the 265 studies (including 32 of the 38 randomized trials) described a positive outcome for anthroposophic treatments—meaning a comparable or a better result than with conventional treatment or a clinically relevant improvement of the condition, often in chronic disease and after unsuccessful conventional treatments. Twelve studies found no benefit, one of them with a negative trend. In one of these 12 studies,43 the standard treatment in the comparison group—intravesical instillation of Bacillus Calmette-Guerin in superficial bladder cancer—was superior.
Mistletoe in Cancer.
Mistletoe treatment for cancer originated within anthroposophic medicine. It is one of the most commonly prescribed complementary cancer therapies in Central Europe44,45 and has been investigated intensely.46,47 Mistletoe (Viscum album L, not to be confused with Phoradendron, the American mistletoe) is a shrub that grows on different host trees. Extracts are made from specific parts of the plant (eg, fresh leafy shoots and berries). Anthroposophic mistletoe preparations (Abnobaviscum, Helixor, Iscador [labeled as “Iscar” in the United States], and Iscucin) are available from different host trees such as oak, apple, and pine. The harvesting procedure is standardized, and the juices from both summer and winter harvests are mixed together.
Mistletoe extract (ME) contains a variety of biologically active compounds,46,47 such as lectins, viscotoxins, other low molecular weight proteins, VisalbCBA (Viscum album chitin-binding agglutinin), oligo- and polysaccharides, flavonoids,48 vesicles,49 triterpene acids,50 and others. ME and several of its compounds are cytotoxic, and the lectins in particular have strong apoptosis-inducing effects.51–53 They also have an effect on multidrug-resistant cancer cells54 and enhance the cytotoxicity of anticancer drugs.55,56 In mononuclear cells, ME possesses DNA-stabilizing properties. ME and its compounds stimulate the immune system (in vivo and in vitro activation of monocytes/macrophages, granulocytes, natural killer cells, T-cells, dendritic cells) and induce a variety of cytokines.46,47 The cytotoxicity of killer cells can also be markedly enhanced by a bridging effect through rhamnogalacturonans.57,58 Injected into tumor-bearing animals, ME and several of its compounds inhibit and reduce tumor growth.46,47 ME also enhances endorphins in vivo.46,47
Clinical studies on mistletoe in cancer describe rather consistently positive effects on quality of life: improved coping, sleep, appetite, energy, ability to work, and emotional and functional well-being, as well as reduced fatigue, exhaustion, nausea, vomiting, depression, and anxiety. Less consistently, the studies describe reduced pain and diarrhea.59 Regarding survival, study results were inconclusive until recently,60,61 and best evidence had rested mainly on epidemiological studies. A well conducted, large, randomized controlled trial has just been concluded; it investigated mistletoe therapy in patients with advanced pancreatic cancer who were not eligible for chemotherapy. The first interim analysis with 220 patients found a statistically significant benefit for survival (primary outcome parameter), with a median survival of 4.8 months in mistletoe-treated patients vs 2.7 months in control patients. Also, quality of life measured as a secondary outcome was superior regarding the functional scales and the symptoms of fatigue, sleep, pain, nausea, vomiting, and appetite. As expected, body weight decreased in control patients but increased in mistletoe-treated patients.62
Tumor remissions are rare in the common low-dose subcutaneous mistletoe therapy.60,61,63 However, they have repeatedly been described following local and high-dose applications of mistletoe extracts, eg, in liver cancer,64 pancreatic cancer,65 Merkel cell carcinoma,66 breast cancer,66 primary cutaneous B-cell lymphoma,67 cutaneous squamous cell carcinoma,68 and others.46,61 Local inflammatory response and fever often are observed at the beginning of treatment, and the tumor then regresses during the next couple of months.
The largest clinical studies on anthroposophic medicine were two system evaluations, together consisting of more than 2700 patients. The Anthroposophic Medicine Outcomes Study (AMOS) is an observational cohort study of German outpatients treated for mental, musculoskeletal, respiratory, and other chronic conditions.70 One hundred fifty-one qualified anthroposophic physicians, 275 therapists, and 1631 patients aged 1 to 75 years participated. At study entry, patients had been ill for 3 years (median) or 6.5 years (mean). Following anthroposophic treatment (art therapy, rhythmical massage, eurythmy therapy, physician-provided counseling, anthroposophic medications), substantial and sustained improvements of disease symptoms and quality of life were observed. The improvements were found in adults70 and children71 in all therapy modality groups72–76 and in all evaluable diagnosis groups (anxiety disorders, asthma, attention deficit/hyperactivity disorder, depression, low back pain, migraine77–83), and the effects were retained after 4 years. The improvements in quality of life were at least of the same order of magnitude as improvements following other (nonanthroposophic) treatments.84 In sensitivity analyses (combined bias suppression), maximally 37% of the improvement could be explained by natural recovery, regression to the mean, adjunctive therapies, and non-response bias.85 In a nested prospective nonrandomized comparative study, AMOS patients with low back pain had comparable or significantly more improvements than patients receiving conventional care.81
The International Integrative Primary Care Outcomes Study on anthroposophic medicine was conducted in four European countries and the United States and compared primary care patients who were treated by anthroposophic or conventional physicians for acute respiratory and ear infections. Compared to conventional therapy, anthroposophic treatment was associated with much lower use of antibiotics and antipyretics as well as quicker recovery, fewer adverse reactions, and greater therapy satisfaction. These differences remained after adjustment for country, age, gender, and four markers of baseline severity. Only 3% of the anthroposophic patients would have agreed to randomization.40
A complex project on anthroposophic healthcare in advanced cancer funded by the Swiss National Science Foundation demonstrated the difficulties of recruiting patients for randomized system comparison even in a university hospital patient population. Although anthroposophic medicine was well integrated into the University Hospital setting and patient compliance with anthroposophic therapy was good, the randomized controlled trial component of the project ultimately had to be abandoned. Still, in the observational part of the study, anthroposophic treatment showed an improvement in physical, psychic, cognitive-spiritual, and social dimensions of quality of life and was perceived by patients as having beneficial effects on physical recovery and well-being, emotional and cognitive-spiritual quality of life, and the quality of human relations and care, while conventional therapy was perceived as beneficial mainly through effects on tumors with alleviation of symptoms and pain.86–89
A system comparison of anthroposophic and conventional healthcare in cancer patients was performed at the University of Uppsala in Sweden. Randomization could not be financed with public funds; therefore, a prospective matched-pair design was implemented. Prior to treatment, quality of life was more compromised in the anthroposophic patients. During and after the anthroposophic treatment, the quality of life improved, whereas the control group treated with conventional medicine showed no change.90,91
Another observational study investigated patients with chronic inflammatory rheumatic conditions receiving anthroposophic healthcare over a 12-month period. They achieved a relevant reduction in the local and systemic inflammatory activity, relief of disease symptoms, and an improvement in functional capacity including the psychosocial dimension. Patient satisfaction was high and conventional therapy could largely be avoided or reduced.92 This study gave rise to a large comparative effectiveness study, comparing anthroposophic with conventional healthcare for patients with rheumatoid arthritis. The study was funded by the German Federal Ministry of Education and Research; it has concluded but has not yet been published.
Another study investigated chronic facial pain (mostly trigeminal neuralgia, present for more than 10 years in half of patients) that had been conventionally treated to no avail. Anthroposophic treatment was followed by clinical improvement (one-fifth of patients became pain-free and almost two-thirds experienced a clear improvement), and conventional therapeutic agents were reduced.93 A retrospective study showed a favorable cure rate of anorexia nervosa following inpatient anthroposophic therapy.94
Clinical Studies on Single or a Fixed Set of Interventions.
A variety of studies has investigated monotherapies or fixed combination therapies, for instance mistletoe treatment in cancer (see above) and in hepatitis,95–97 betulin-based oleogel in actinic keratosis,98,99 rhythmic embrocation (with Solum oil) in chronic pain,100 hepar magnesium in seasonal fatigue symptoms,101 arnica/echinacea in care of umbilical cords of newborns,102,103 eurythmy therapy in attention deficit/hyperactivity disorder104, body-temperature enemas in febrile children,105 mistletoe combined with Articulatio coxae or genus D30 in osteoarthritis of the hip and knee,106 Gelsemium comp. in acute occipital muscular pain,107 and many others. Most studies, except one on migraine,108 one on postoperative wound care,109 and one on actinic keratosis,99 showed positive results. Four recent new randomized controlled trials—on Disci/Rhus toxicodendron comp. in chronic low back pain,110 on Articulatio genus D5 in ostheoarthritis of the knee,111 on calendula cream in skin care during radiation,112 and on Ovaria comp. in menopausal symptoms113—found no benefit compared to placebo treatment.
Patient satisfaction was generally high, and therapeutic expectations were fulfilled.13,42,114 For instance, in a recently completed Dutch survey (Consumer Quality Index, a national standard to measure healthcare quality from the perspective of healthcare users), 2.099 patients reported very high satisfaction with anthroposophic primary care practices (8.4 and 8.3 on a scale of 0 to 10, 10 being the best possible score).115
A variety of investigations specifically assessed the safety of anthroposophic treatments.13,69,72–74,116–119 In general, the tolerability is good. Adverse reactions are infrequent and mostly mild to moderate in severity. Three types of adverse reactions to anthroposophic medications are commonly described: local reactions from topical application, systemic hypersensitivity including very rare cases of anaphylactic reactions, and aggravation of preexisting symptoms in sensitive patients. In a detailed safety analysis from the AMOS study, the incidence of confirmed adverse reactions to anthroposophic medications was 3% of users and 2% of the medications used116; adverse reactions in eurythmy therapy, art therapy, and rhythmical massage were reported in 3%, 1%, and 5% of the patients, respectively72–74; and no serious adverse reactions were found.116 Theoretically, avoidance of necessary conventional treatment in anthroposophic healthcare settings might pose a risk, but no evidence has been found for this.13,42 Comparative studies found similar81 or lower40,114,120 rates of side effects in anthroposophic than in conventional healthcare.
Several economic analyses assessed costs of anthroposophic medicine. They point to a favorable cost structure and found cost savings partly due to lower drug costs, fewer specialist referrals, and fewer hospital days and admissions. This cannot be explained by a reduced disease burden—on the contrary, in most studies, anthroposophically treated patients are more severely affected or have been ill for a longer period before starting therapy.13,121–125
Case report methodology has been developed to provide validated and transparent information from the point of care with special focus on individualized healthcare.126–130 Case reports describe the specific anthroposophic treatment approach in detail (eg, see references 27, 67, 68, 131, and 132). Methods for systematic and critical appraisal still have to be worked out.
Anthroposophic medicine is an example of a multimodal treatment system—based on a holistic paradigm of the organism, disease, and treatment—that can be fully integrated with conventional medicine in medical practices and hospitals. Great emphasis is put on individualized healthcare. Assessing this healthcare system, an integrative evaluation strategy has been applied, including system approaches as well as studies in isolated treatment components with regard to efficacy, effectiveness, safety, and costs, as well as qualitative methods and high-quality case reports on individual treatment.
Disclosures The authors completed the ICMJE Disclosure Form for Potential Conflicts of Interest and had no conflicts related to this work to disclose.
Gunver S. Kienle, Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke, Germany. European Scientific Cooperative on Anthroposophic Medicinal Products (ESCAMP), Freiburg, Germany.
Hans-Ulrich Albonico, Clinic for Family and Complementary Medicine, Langnau im Emmental, Switzerland.
Erik Baars, European Scientific Cooperative on Anthroposophic Medicinal Products (ESCAMP), Freiburg, Germany. University of Applied Sciences Leiden, The Netherlands; Louis Bolk Institute, Driebergen, The Netherlands.
Harald J. Hamre, Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke, Germany, Norway. European Scientific Cooperative on Anthroposophic Medicinal Products (ESCAMP), Freiburg, Germany.
Peter Zimmermann, Department of Gynecology, Plusterveys, Nastola Medical Center, Finland.
Helmut Kiene, Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke, Germany.
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